The Protein Benders!
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Selected Publications
Check all our publications on Google Scholars.
Peptide design and studying
Design and structure validation of peptide-drug conjugate ligands of the kappa-opioid receptor
Edin Muratspahić, Kristine Deibler, Jianming Han, Nataša Tomašević, Kirtikumar B Jadhav, Aina-Leonor Olivé-Marti, Nadine Hochrainer, Roland Hellinger, Johannes Koehbach, Jonathan F Fay, Mohammad Homaidur Rahman, Lamees Hegazy, Timothy W Craven, Balazs R Varga, Gaurav Bhardwaj, Kevin Appourchaux, Susruta Majumdar, Markus Muttenthaler, Parisa Hosseinzadeh, David J Craik, Mariana Spetea, Tao Che, David Baker, Christian W Gruber, Nature Communications 2023 (Article)
Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites
Parisa Hosseinzadeh, Paris Watson†, Timothy W. Craven†, Xinting Li†, Stephen A. Rettie†, Fátima Pardo-Avila, Asim K. Bera, Vikram Khipple Mulligan, Peilong Lu, Alexander S. Ford, Brian D. Weitzner, Lance J. Stewart, Adam P. Moyer, Maddalena Di Piazza, Joshua G. Whalen, Per Jr. Greisen, David W. Christianson, David Baker; Nature Communications 2021 (Article)
Comprehensive computational design of ordered peptide macrocycles
Parisa Hosseinzadeh*, Gaurav Bhardwaj*, Vikram Khipple Mulligan*, Matthew D. Shortridge, Timothy W. Craven, Fátima Pardo-Avila, Stephen A. Rettie, David E. Kim, Daniel-Adriano Silva, Yehia M. Ibrahim, Ian K. Webb, John R. Cort, Joshua N. Adkins, Gabriele Varani, David Baker; Science 2017 (Pubmed)
Enzyme design and studying
Isolating conformers to assess dynamics of peptidic catalysts using computationally designed macrocyclic peptides
Elizabeth A. Stone, Parisa Hosseinzadeh, Timothy W. Craven, Michael J. Robertson, Yaodong Han, Sheng-Ying Hsieh, Anthony J. Metrano, David Baker, Scott J. Miller; ACS Catalysis 2021 (Article)
A designed heme-[4Fe-4S] metalloenzyme catalyzes sulfite reduction like the native enzyme
Evan N. Mirts, Igor D. Petrik, Parisa Hosseinzadeh, Mark J. Nilges, Yi Lu; Science 2018 (Article)
Design of a single protein that spans the entire 2-V range of physiological redox potentials
Parisa Hosseinzadeh*, Nicholas M. Marshall*, Kelly N. Chacón, Yang Yu, Mark J. Nilges, Siu Yee New, Stoyan A. Tashkov, Ninian J. Blackburn, Yi Lu; Proc Natl Acad Sci 2016 (Article)
Reviews and Views
Promising developments in the design of protein binders
Alonso Cruz, Parisa Hosseinzadeh, GEN Biotechnology 2022, (Article)